Heparan Sulfate Analog Technology:

Meet the revolutionary repairing molecule used and recommended by 500+ dermatologists to promote even skin tone in every complexion.

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Does your skincare contain the breakthrough repairing molecule?

What is Heparan Sulfate?

Like hyaluronic acid, heparan sulfate belongs to the glycosaminoglycan family of naturally occurring water-binding molecules found throughout our body.

What does it do?

Along with being an excellent skin hydrator, heparan sulfate orchestrates our skin’s immune response to inflammation and enables the repair process of skin cells. With age, the amount of heparan sulfate in your body decreases which leads to chronic skin inflammation. This inflammation is responsible for facial redness, and visible signs of aging among other skin concerns.

Heparan Sulfate is a naturally occurring
component of your skin that is essential
to maintaining skin health

Learn from a dermatologist: Heparan Sulfate

Meet Heparan Sulfate Analog (HSA) - Senté's Exclusive Breakthrough Repairing Molecule

Senté is the first and only brand to successfully design a low molecular weight version of heparan sulfate, which allows it to be readily absorbed. Our patented and proprietary Heparan Sulfate Analog (HSA) molecule mimics the effects of heparan sulfate, providing a natural boost to your skin’s immune response to inflammation and promoting repair from within.

Learn from a dermatologist: Heparan Sulfate Analog (HSA)

What are the benefits of HSA for your skin?

Senté’s skincare products with revolutionary repairing HSA are made with sensitive skin in mind and have been scientifically shown to:

Reduce visible redness

Promote deep hydration

Strengthen barrier function

Decrease the appearance of uneven skin tone

Improve appearance of fine lines

Visible Improvements in skin tone evenness

Experience reduction in persistent redness after 2 weeks

In a clinical study using Dermal Repair Cream:

79% of subjects with sensitive skin agreed that their skin was less sensitive and irritated after 2 weeks

70% of subjects with sensitive skin showed a visible reduction in redness after 4 weeks

Improve the appearance of skin tone evenness by week 8

In a clinical study using Dermal Repair Cream:

76% of subjects agreed that their skin tone was more even after 4 weeks.

Better Together

HSA helps prevent irritation and enhances results

HSA + Retinol

HSA strengthens the skin barrier and improves tolerability when paired with prescription retinoids or retinol products.

HSA + pigmentation correcting ingredients

HSA helps prevent inflammation induced- pigmentation.

HSA + In-office treatments

HSA is also recommended for use with peels, micro-needling, and non-ablative laser treatments among others.

Your Skincare Routine With HSA


2.Moisturize and Repair



2.Retinol Renewal

3.Moisturize and Repair

Learn from a dermatologist: Adding HSA to your skicare routine

Learn from Dermatologist Annabelle Garcia, MD about Heparan Sulfate Analog:

What is Heparan Sulfate and where is it found?

Just like hyaluronic acid, heparan sulfate belongs to the glycosaminoglycan family of water binding molecules. This naturally occurring molecule is known for being an excellent skin hydrator.

What does Heparan Sulfate do?

Heparan sulfate is found on the surface of all healthy cells and plays an essential role in our skin’s immune response to inflammation. As we age, our natural levels of heparan sulfate become fatigued and diminish, which can cause an imbalance. This can result in prolonged inflammation, where your skin’s self-defense mechanisms have been compromised.

What is HSA?

HSA is Heparan Sulfate Analog. Heparan Sulfate Analog is Senté’s patented technology that supports the skin’s ability to repair from within. It’s a form of Heparan Sulfate, which is found naturally in our skin that is vital to skin health and repair. HS needs to be replenished in the skin regularly, and the most effective way to do so is by using products that contain HSA, because it has been created specifically for optimal absorption.

What does HSA do for my skin?

Heparan Sulfate Analog (HSA) helps replenish skin's depleted heparan sulfate levels, providing a natural boost to your skin’s immune response. By helping your skin defend itself from stressors, HSA supports the skin’s natural ability to repair itself, reducing the appearance of red, dry, and uneven skin while also improving the appearance of fine lines and wrinkles.

Don’t I already get that in other products?

While you might be using products that contain Hyaluronic Acid, which is in the same family of hydrators, Heparan Sulfate Analog is only available in products from Senté, as they hold the patent on the ingredient and its use in skin care products.

Can I use it with other products/ingredients?

HSA plays well with all other ingredients, which makes it easy to add to a skincare regimen without any concerns for interactions or irritation. In fact, HSA is proven to improve deep hydration and reduce sensitivity in and on the skin. This might, in some cases, help your skin tolerate other products in your regimen much better.

When will I see a difference?

You will likely start to notice that your skin is more hydrated in 2-4 weeks, along with improvements in the amount of redness you see on your skin as well. The longer you use it, you will continue to see more hydration, less redness and sensitivity and the other signs of aging that are caused by the inflammation that is linked to visible redness.

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